One particular affected individual discontinued drug on account of average abdominal cramping and unfastened stools, when another affected person discontinued drug due to mild vaginal burning. These signs and symptoms settled after discontinuation of drug.

Oral metronidazole continues to be reported to potenti-ate the anticoagulant outcome of coumarin and warfarin causing a prolongation of prothrombin time. The outcome of topical metronida-zole on prothrombin time is not really known.

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A number of extensive-time period oral studies during the rat have demonstrated statistically significant boosts in mammary and hepatic tumors at doses >885 mg/m²/working day.

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